Hey,
Short gaps in employment may get unnoticed but if you have a longer period of gap, it is wise to stick with the truth. If you really have a valid personal reason then go for a good explanation, that should not portray as a makeup story or something.
Try to highlight what you have done in that time period, like if you have learned any technology or done some training as to industry level. This will tell the interviewer that you have been productive during this and period and working on your skills.