It depends on the objective of the Blockchain that you want to start up. Also, it depends on if you want to have an open or a private Blockchain. If you want to start up a private Blockchain, i.e. the acces to the Blockchain is controled and the data isn't open, I suggest you to start reading about Hyperledger Fabric. On the other hand, if you want to start up a public Blockchain, i.e. everyone would acces to the Blockchain and the would be open, I suggest you to start reading about Ethereum. I