You can use pd.Series.isin.
For "IN" use: something.isin(somewhere)
Or for "NOT IN": ~something.isin(somewhere)
For example, 
>>> df
  countries
0        US
1        UK
2   Germany
3     China
>>> countries
['UK', 'China']
>>> df.countries.isin(countries)
0    False
1     True
2    False
3     True
Name: countries, dtype: bool
>>> df[df.countries.isin(countries)]
  countries
1        UK
3     China
>>> df[~df.countries.isin(countries)]
  countries
0        US
2   Germany