Python is RuntimeError acceptable for general use

Question

Is it acceptable to use the RuntimeError exception for general application use?

raise RuntimeError('config file is missing host address')

I've got some code with a couple of one-off situations like this and would prefer to avoid creating one-off exception classes for each of them. All the situations are fatal, and my goal is to get a clear message to the console. Basically I'm looking for something similar to the deprecated

raise 'config file is missing host address'